Apoptosis and senescence in cancer chemotherapy and radiotherapy /
Provides insight into established practices and research into apoptosis and senescence by examining techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. This boo...
| Other Authors: | , , |
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| Format: | Book |
| Language: | English |
| Published: |
Totowa, N.J. : Oxford :
Humana ; Blackwell [distributor],
2006
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| Edition: | 2nd ed |
| Series: | Cancer drug discovery and development
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| Subjects: |
Table of Contents:
- Front Matter; The Intrinsic Pathway of Apoptosis; The Extrinsic Pathway of Apoptosis; Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival; Mitotic Catastrophe; Autophagy and Autophagic Cell Death; Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis; Structure and Function of the Telomere; Overview of Senescence; Contributions of Telomerase to Tumorigenesis; The Role of Telomeres in Genomic Instability; Overview of the DNA Damage Checkpoint
- Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in CancerInterplay Between .H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Response; DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy; Resistance/Signaling Pathways; Ceramide and Multidrug Resistance; Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling; The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy; Antimetabolites; Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes
- Perturbations of Cellular Functions by Topoisomerase II InhibitorsThe Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs; Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents; Tyrosine Kinase Inhibitors; Monoclonal Antibodies in Lymphomas; Role of Apoptosis in Anti-Angiogenic Cancer Therapies; Photodynamic Therapy-Induced Apoptosis; Modulation of TRAIL Signaling for Cancer Therapy; Back Matter