Osteoblasts : morphology, functions and clinical implications /
Other Authors: | |
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Format: | Book |
Language: | English |
Published: |
New York :
Nova Science Publishers,
[2013]
|
Series: | Cell biology research progress
Muscular system--anatomy, functions, and injuries series |
Subjects: |
Table of Contents:
- Intro
- OSTEOBLASTS
- OSTEOBLASTS
- Contents
- Preface
- Osteoblasts under Mechanical Strain
- Abstract
- Abbreviations
- 1. Introduction
- 1.1. Bone Tissue Cellular Structure
- 1.2. Osteoblasts
- 1.2.1. Osteoblast Origin and Life Cycle
- 1.2.2. Osteoblast Function
- 1.2.3. Growth Factor and Hormone Effects on Osteoblasts
- 1.3. Runx2 Transcription Factor in Bone Biology
- 1.3.1. Runx2 in Osteoblast Differentiation
- 1.3.2. Structure of Runx2 Gene
- 1.3.3. Runx2 Expression
- 2. Bone Remodeling
- 2.1. Regulation of Bone Remodeling
- 2.2. The Role of the RANK / RANKL / OPG System in Bone Remodeling
- 2.3. Bone Remodeling Pathophysiology
- 3. Mechanotransduction
- 3.1. Bone Remodeling and Mechanotransduction
- 3.2. Runx2 in Mechanotransduction
- 3.3. Nuclear Factor Î#x9A;appa B (NF-κÎ#x92;) Transcription Factor in Mechanotransduction
- 3.4. Polycystins in Mechanotransduction
- 3.5. Model Systems for the Study of Mechanotransduction in Osteoblasts
- 3.6. The Role of Mechanotransduction in Bone Disease
- 3.7. Mechanical Stimulation as a Therapeutic Strategy against Bone Disease
- Conclusion
- References
- From Stem Cells to Osteoblast: Therapeutic Potential for Bone Tissue Engineering
- Abstract
- Introduction
- Mesenchymal Stem Cells
- Differentiation of MSC into Osteoblast
- Role of Growth Factors and Transcription Factors in Osteoblast Differentiation
- Role of Transcription Factor in Differentiation of Osteoblast
- Scaffolds
- Natural Scaffolds: Extracellular Matrix
- Glycosaminoglycans (GAGs)
- Chitosan Scaffold
- Tripolymer Scaffolds
- References
- Osteoblast Functions and their Role in Skeletal Bone Diseases
- Abstract
- Introduction
- Osteoblast Lineage and Differentiation
- Transcription Factors, Signaling Proteins and Osteoblast Differentiation
- Osteoblast Migration
- Osteoblasts and Bone Diseases
- Intro
- OSTEOBLASTS
- OSTEOBLASTS
- Contents
- Preface
- Osteoblasts under Mechanical Strain
- Abstract
- Abbreviations
- 1. Introduction
- 1.1. Bone Tissue Cellular Structure
- 1.2. Osteoblasts
- 1.2.1. Osteoblast Origin and Life Cycle
- 1.2.2. Osteoblast Function
- 1.2.3. Growth Factor and Hormone Effects on Osteoblasts
- 1.3. Runx2 Transcription Factor in Bone Biology
- 1.3.1. Runx2 in Osteoblast Differentiation
- 1.3.2. Structure of Runx2 Gene
- 1.3.3. Runx2 Expression
- 2. Bone Remodeling
- 2.1. Regulation of Bone Remodeling
- 2.2. The Role of the RANK / RANKL / OPG System in Bone Remodeling
- 2.3. Bone Remodeling Pathophysiology
- 3. Mechanotransduction
- 3.1. Bone Remodeling and Mechanotransduction
- 3.2. Runx2 in Mechanotransduction
- 3.3. Nuclear Factor Î#x9A; appa B (NF-κÎ#x92; ) Transcription Factor in Mechanotransduction
- 3.4. Polycystins in Mechanotransduction
- 3.5. Model Systems for the Study of Mechanotransduction in Osteoblasts
- 3.6. The Role of Mechanotransduction in Bone Disease
- 3.7. Mechanical Stimulation as a Therapeutic Strategy against Bone Disease
- Conclusion
- References
- From Stem Cells to Osteoblast: Therapeutic Potential for Bone Tissue Engineering
- Abstract
- Introduction
- Mesenchymal Stem Cells
- Differentiation of MSC into Osteoblast
- Role of Growth Factors and Transcription Factors in Osteoblast Differentiation
- Role of Transcription Factor in Differentiation of Osteoblast
- Scaffolds
- Natural Scaffolds: Extracellular Matrix
- Glycosaminoglycans (GAGs)
- Chitosan Scaffold
- Tripolymer Scaffolds
- References
- Osteoblast Functions and their Role in Skeletal Bone Diseases
- Abstract
- Introduction
- Osteoblast Lineage and Differentiation
- Transcription Factors, Signaling Proteins and Osteoblast Differentiation
- Osteoblast Migration
- Osteoblasts and Bone Diseases
- Laboratory Experiments
- (1) Cellular Proliferation
- (2) Alkaline Phosphatase Activity Assays (ALP)
- (3) Mineralization Assay
- Conclusion
- References
- Index
- Osteoporosis
- Osteoarthritis
- Osteogenesis Imperfecta
- Van Buchem Disease and Sclerosteosis
- Oculodentodigital Dysplasia
- Camurati-Engelmann Disease
- Cleidocranial Dysplaysia
- Osteoblastic Bone Metastasis
- Acknowledgment
- References
- Osteoblast Differentiation and Related Diseases
- Abstract
- Introduction
- A. Transcription Factors Regulating Osteoblast Differentiation
- RUNX2
- TWIST1
- MSX1 and MSX2
- SP7/Osterix
- β-Catenin
- ATF4
- FoxO1
- B. Diseases Associated with Osteogenic Transcription Factors
- Cleidocranial Dysplasia (CCD)
- Saethre Chotzen Syndrome (SCS)
- Boston-Type Craniosynostosis
- Non-Collagenous Osteogenesis Imperfecta Caused by SP7/OSX Mutation
- Coffin-Lowry Syndrome (CLS)
- Neurofibromatosis Type I
- Conclusion
- References
- BMP and Osteoblastogenesis Inhibitors
- Abstract
- Bone Morphogenetic Proteins
- BMP-Smad Signaling
- Extracellular Inhibitor
- Cytomembrane Inhibitors
- Intracellular Inhibitors
- Nuclear Inhibitors, Which Interact with Runx2 or Osx
- MicroRNAs
- Prospect for Future Therapy
- References
- The Effect of Molecular and Biochemical Differentiation Agentson Bone Formation
- Abstract
- Introduction
- Osteoblast Differentiation and Inducer Materials
- Standard Medium for Osteogenic Cultures
- Medium Supplements
- Ascorbic Acid
- 1. The Effect of Ascorobic Acid on Osteoclast Formation
- 2. The Effect of Ascorbic Acid on Osteoblast Formation
- B-Glycerophosphate (BGP)
- Dexamethasone (Dex)
- Vitamin D3
- Bone Morphogenic Protein 2(BMP-2)
- Collagen I and Vetronectin
- Conclusion and Further Remarks
- References
- Evaluation of Characteristics of Osteoblasts and Factors Relatedto Osteoblastic Differentiation and Mineralization
- Abstract
- Introduction
- Characteristics of Osteblast
- Bone Morphogenetic Protein (BMP)
- Various Agents
- Osteoporosis
- Osteoarthritis
- Osteogenesis Imperfecta
- Van Buchem Disease and Sclerosteosis
- Oculodentodigital Dysplasia
- Camurati-Engelmann Disease
- Cleidocranial Dysplaysia
- Osteoblastic Bone Metastasis
- Acknowledgment
- References
- Osteoblast Differentiation and Related Diseases
- Abstract
- Introduction
- A. Transcription Factors Regulating Osteoblast Differentiation
- RUNX2
- TWIST1
- MSX1 and MSX2
- SP7/Osterix
- β-Catenin
- ATF4
- FoxO1
- B. Diseases Associated with Osteogenic Transcription Factors
- Cleidocranial Dysplasia (CCD)
- Saethre Chotzen Syndrome (SCS)
- Boston-Type Craniosynostosis
- Non-Collagenous Osteogenesis Imperfecta Caused by SP7/OSX Mutation
- Coffin-Lowry Syndrome (CLS)
- Neurofibromatosis Type I
- Conclusion
- References
- BMP and Osteoblastogenesis Inhibitors
- Abstract
- Bone Morphogenetic Proteins
- BMP-Smad Signaling
- Extracellular Inhibitor
- Cytomembrane Inhibitors
- Intracellular Inhibitors
- Nuclear Inhibitors, Which Interact with Runx2 or Osx
- MicroRNAs
- Prospect for Future Therapy
- References
- The Effect of Molecular and Biochemical Differentiation Agentson Bone Formation
- Abstract
- Introduction
- Osteoblast Differentiation and Inducer Materials
- Standard Medium for Osteogenic Cultures
- Medium Supplements
- Ascorbic Acid
- 1. The Effect of Ascorobic Acid on Osteoclast Formation
- 2. The Effect of Ascorbic Acid on Osteoblast Formation
- B-Glycerophosphate (BGP)
- Dexamethasone (Dex)
- Vitamin D3
- Bone Morphogenic Protein 2(BMP-2)
- Collagen I and Vetronectin
- Conclusion and Further Remarks
- References
- Evaluation of Characteristics of Osteoblasts and Factors Relatedto Osteoblastic Differentiation and Mineralization
- Abstract
- Introduction
- Characteristics of Osteblast
- Bone Morphogenetic Protein (BMP)
- Various Agents