Inflammatory mechanisms in mediating hearing loss /
The primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be...
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| Other Authors: | , |
| Format: | Book |
| Language: | English |
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Cham :
Springer International Publishing : Imprint: Springer,
2018
Cham, Switzerland : Springer, [2018] |
| Subjects: |
Table of Contents:
- Intro; Preface; Contents; Contributors; Chapter 1: The Cochlea; 1 Fluid Spaces intheCochlea; 2 Cochlear Duct; 3 Tectorial Membrane; 4 Basilar Membrane; 5 The Lateral Wall oftheCochlea; 6 The Spiral Ligament; 7 Stria Vascularis; Basal Cells; 8 Endocochlear Potential; 9 Organ of Corti; 10 Mechano-transduction; 11 Hair Cell Synapses; References; Chapter 2: Oxidative Stress and Hearing Loss; 1 Introduction; 2 Oxidative Stress; Free Radicals; Oxidative Stress and Cytotoxicity; 3 Cochlear Targets of Oxidative Stress; Sensory Epithelium; Lateral Wall; Modiolus
- Intro; Preface; Contents; Contributors; Chapter 1: The Cochlea; 1 Fluid Spaces intheCochlea; 2 Cochlear Duct; 3 Tectorial Membrane; 4 Basilar Membrane; 5 The Lateral Wall oftheCochlea; 6 The Spiral Ligament; 7 Stria Vascularis; Basal Cells; 8 Endocochlear Potential; 9 Organ ofCorti; 10 Mechano-transduction; 11 Hair Cell Synapses; References; Chapter 2: Oxidative Stress andHearing Loss; 1 Introduction; 2 Oxidative Stress; Free Radicals; Oxidative Stress andCytotoxicity; 3 Cochlear Targets ofOxidative Stress; Sensory Epithelium; Lateral Wall; Modiolus
- Preface
- The Cochlea
- Oxidative Stress and Hearing Loss
- Corticotropin Releasing Factor Signaling in the Mammalian Cochlea: An Integrative Niche for Cochlear Homeostatic Balance Against Noise
- Cochlear vascular pathology and hearing loss
- Cochlear Inflammation Associated with Noise-Exposure
- Middle Ear Infection and Hearing Loss
- Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss
- The Contribution of Anti-Oxidant and Anti-Inflammatory Functions of Adenosine A1 Receptor In Mediating Otoprotection
- Anti-inflammatory therapies for sensorineural hearing loss
- Implementation and Outcomes of Clinical Trials in Immune-Mediated Hearing Loss and other Rare Diseases
- Index
- 2 Bounds Related toCurrent Perspectives of Noise-Induced Damage and Functional Loss: Cellular Elements of CochleaTemporary Threshold Shifts (TTS) and Associated Cellular Elements atRisk forDamage; Previously Described Protective Mechanisms Against NIHL; 3 Elements of Corticotropin Releasing Factor (Hormone) Signaling Systems, and Their Expression intheMammalian Inner Ear; A Novel Theory of Local Cochlear Signaling Systems Protective AgainstCellular Damage and Associated NIHL; 4 Inflammatory/Immune Responses intheCochlea Are Driven by Acoustic Over-Exposure
- 2 Bounds Related toCurrent Perspectives ofNoise-Induced Damage andFunctional Loss: Cellular Elements ofCochleaTemporary Threshold Shifts (TTS) andAssociated Cellular Elements atRisk forDamage; Previously Described Protective Mechanisms Against NIHL; 3 Elements ofCorticotropin Releasing Factor (Hormone) Signaling Systems, andTheir Expression intheMammalian Inner Ear; A Novel Theory ofLocal Cochlear Signaling Systems Protective AgainstCellular Damage andAssociated NIHL; 4 Inflammatory/Immune Responses intheCochlea Are Driven byAcoustic Over-Exposure
- 4 Oxidative Stress inAcquired Hearing LossEnvironmental Exposures; Therapeutic Drugs and Agents; Aging; 5 Interventional Approaches and Challenges; Biomarkers of Oxidative Stress; Otoprotection by Targeting Oxidative Stress; Potential Interference with Cell Signaling and Drug Activity; References; Chapter 3: Corticotropin Releasing Factor Signaling intheMammalian Cochlea: AnIntegrative Niche forCochlear Homeostatic Balance Against Noise; 1 Introduction; The Evolution of Hypotheses ConcerningNoise-Induced Hearing Loss
- 4 Oxidative Stress inAcquired Hearing LossEnvironmental Exposures; Therapeutic Drugs andAgents; Aging; 5 Interventional Approaches andChallenges; Biomarkers ofOxidative Stress; Otoprotection by Targeting Oxidative Stress; Potential Interference withCell Signaling andDrug Activity; References; Chapter 3: Corticotropin Releasing Factor Signaling intheMammalian Cochlea: AnIntegrative Niche forCochlear Homeostatic Balance Against Noise; 1 Introduction; The Evolution ofHypotheses ConcerningNoise-Induced Hearing Loss
- CRF Signaling Is Involved withtheInflammatory Process5 Local (Cochlear) CRF Signaling VersusSystemic HPA Axis: ATale of Timing, Balance of Mechanistic Actions, and Direct VersusIndirect Signaling; The Indirect CRF Signaling System; The Direct CRF Signaling System, and Its Potential Role inCochlear Function and Protection from Noise-Induced Damage; 6 Of Glucocorticoids, Clocks, Entrainment, andaPotential Interaction BetweenSystemic and Peripheral CRF Signaling Systems Important forInflammatory Responses intheCochlea; Glucocorticoid Function; Glucocorticoid Receptors
- CRF Signaling Is Involved withtheInflammatory Process5 Local (Cochlear) CRF Signaling VersusSystemic HPA Axis: ATale ofTiming, Balance ofMechanistic Actions, andDirect VersusIndirect Signaling; The Indirect CRF Signaling System; The Direct CRF Signaling System, andIts Potential Role inCochlear Function andProtection fromNoise-Induced Damage; 6 Of Glucocorticoids, Clocks, Entrainment, andaPotential Interaction BetweenSystemic andPeripheral CRF Signaling Systems Important forInflammatory Responses intheCochlea; Glucocorticoid Function; Glucocorticoid Receptors
- Physiological OscillationsThe Master Clock oftheSuprachiasmatic Nucleus; Peripheral Clocks; 7 A Confluence of Biological Disciplines That Includes Circadian Biology, Immunology, and Cochlear Molecular Neurobiology Converge toSuggest aRole forCochlear CRF Signaling inModulating Inflammatory Responses intheCochlea; A Theory of Cochlear Inflammatory Response toTraumatic Noise Would Include the Following Aspects of Signaling; 8 Conclusions; References; Chapter 4: Cochlear Vascular Pathology and Hearing Loss; 1 Introduction; 2 Blood Supply totheLateral Wall
- Physiological OscillationsThe Master Clock oftheSuprachiasmatic Nucleus; Peripheral Clocks; 7 A Confluence ofBiological Disciplines That Includes Circadian Biology, Immunology, andCochlear Molecular Neurobiology Converge toSuggest aRole forCochlear CRF Signaling inModulating Inflammatory Responses intheCochlea; A Theory ofCochlear Inflammatory Response toTraumatic Noise Would Include theFollowing Aspects ofSignaling; 8 Conclusions; References; Chapter 4: Cochlear Vascular Pathology andHearing Loss; 1 Introduction; 2 Blood Supply totheLateral Wall