Triple-Negative Breast Cancer
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| Format: | Book |
| Language: | English |
| Published: |
Hauppauge :
Nova Science Publishers, Inc.,
2017
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| Series: | Cancer etiology, diagnosis, and treatments
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| Subjects: |
Table of Contents:
- Preface; Chapter 1; The Role of Exosomes in Breast Cancer: What Have We Learned in Ten Years?; Abstract; Introduction; Exosomes: An Overview; Exosomes: In Cancer; Cancer-Associated Exosomes Containing Proteins; Cancer-Associated Exosomes Containing Nucleic Acids; miRNA-containing Exosomes; mRNA-Containing Exosomes; DNA-containing Exosomes; Cancer-Associated Exosomes Containing Lipids; Exosomes in the Breast Tumor Microenvironment; Exosomes in Hypoxia, Epithelial
- Mesenchymal Transition, ROS Production and Autophagy; Exosomes in Metastasis; Exosomes and Drug Resistance
- Conclusion and Future PerspectivesReferences; Chapter 2; Correlations between BRCA Gene Mutations and the High Risk of TNBC as Defined by the Defect of Estrogen Signaling; Abstract; Introduction; Interplay Between Endogenous Estrogens and Wild-Type BRCA Genes; Correlations between BRCA Gene Mutations and Defective Estrogen Signaling; Decreased ER-Alpha Expression in BRCA Gene Mutation Carrier Cells; Decreased Estradiol-Liganded Transcriptional Activity of ERs in BRCA Gene Deficient Cells; Defensive Counteractions Against BRCA Gene Defects
- Increased Aromatase Activity Associated with BRCA Gene MutationHyperestrogenism as a Compensatory Mechanism in Women with BRCA Gene Mutation; Increased Ligand-Independent Transcriptional Activity in Cells with BRCA1 Mutation; Hormonal Risk Factors for Overall Breast Cancer and TNBC; Correlations between Menopausal Status and TNBC Risk; Correlations between Reproductive History and the Risk of Different Breast Cancer Subtypes; Conclusion; References; Chapter 3; The Role of Tumor Infiltrating Lymphocytes (TILs) in Triple Negative Breast Cancer (TNBC); Abstract; Introduction
- Pathologic and Molecular Heterogeneity of TNBCTumor-Infiltrating Lymphocytes in TNBC; a. TILs as a Prognostic Factor; b. TILs as a Predictive Factor; c. TILs as Biomarkers of Residual Disease; Targeting the Immune System in Triple-Negative Breast Cancer: Potential Role of the PD-1/PD-L1 Pathway as a Biomarker; Conclusion; References; Index; Blank Page