Checkpoint responses in cancer therapy /
Extensive research has uncovered a set of molecular surveillance mechanisms-commonly called "checkpoints"-that tightly monitor cell-cycle processes. Today's anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now prom...
| Other Authors: | , |
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| Format: | Book |
| Language: | English |
| Published: |
Totowa, NJ :
Humana Press,
2008
Totowa, N.J. : Humana, 2008 |
| Series: | Cancer drug discovery and development
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| Subjects: |
Table of Contents:
- 1 RB-Pathway: Cell Cycle Control and Cancer Therapy / Erik S. Knudsen, Wesley A. Braden 1
- 2 Targeting the p53/MDM2 Pathway for Cancer Therapy / Christian Klein, Lyubomir T. Vassilev 19
- 3 DNA Topoisomerases as Targets for the Chemotherapeutic Treatment of Cancer / Ryan P. Bender, Neil Osheroff 57
- 4 Targeting ATM/ATR in the DNA Damage Checkpoint / Joseph M. Ackermann, Wafik S. El-Deiry 93
- 5 Compounds that Abrogate the G2 Checkpoint / Takumi Kawabe 117
- 6 CDK Inhibitors as Anticancer Agents / Timothy A. Yap, L. Rhoda Molife, Johann S. de Bono 135
- 7 CHFR as a Potential Anticancer Target / Minoru Toyota, Lisa Kashima, Takashi Tokino 163
- 8 Antimicrotubule Agents / Miguel A. Villalona-Calero, Larry Schaaf, Robert Turowski 177
- 9 Kinesin Motor Inhibitors as Effective Anticancer Drugs / Vasiliki Sarli, Athanassios Giannis 207
- 10 Targeting the Spindle Checkpoint in Cancer Chemotherapy / Jungseog Kang, Hongtao Yu 227
- 11 Antiproliferation Inhibitors Targeting Aurora Kinases / Kishore Shakalya, Daruka Mahadevan 243
- 12 Plks as Novel Targets for Cancer Drug Design / Wei Dai, Yali Yang, Ning Jiang 271
- 13 Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin Structure? / Brian Gabrielli, Frankie Stevens, Heather Beamish 291