Genetic toxicology and cancer risk assessment /
Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwid...
| Other Authors: | |
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| Format: | Book |
| Language: | English |
| Published: |
New York :
Marcel Dekker,
2001
New York : [2001], ©2001 New York : c2001 New York : [2001] |
| Subjects: |
Table of Contents:
- Human cancer genetics
- Genetic toxicity for predicting carcinogenicity
- Genotoxic and nongenotoxic mechanisms of carcinogenesis
- Structure-activity relationship (SAR) and its role in cancer risk assessment
- Regulatory genetic toxicology tests
- Complementary genetic toxicology assays
- The mouse lymphoma assay (MLA) using the microwell method
- The in vivo micronucleus assay
- ICH guidances on genotoxicity and carcinogenicity: scientific background and regulatory practice
- New OECD genetic toxicology guidelines and interpretation of results
- Dose-response relationships in chemical carcinogenesis and cancer risk assessment
- Molecular epidemiology and biomarkers
- Quantitative cancer risk assessment of nongenotoxic carcinogens
- Risk assessment of genotoxic carcinogens
- Biologically based cancer risk assessment models
- 1 Human Cancer Genetics / Jason W. Barlow and David Malkin
- 2. Genetic Toxicity Tests for Predicting Carcinogenicity / Errol Zeiger
- 3. Genotoxic and Nongenotoxic Mechanisms of Carcinogenesis / Wai Nang Choy
- 4. Structure-Activity Relationship (SAR) and Its Role in Cancer Risk Assessment / David Y. Lai and Yin-tak Woo
- 5. Regulatory Genetic Toxicology Tests / Wai Nang Choy
- 6. Complementary Genetic Toxicology Assays / B. Bhaskar Gollapudi
- 7. The Mouse Lymphoma Assay (MLA) Using the Microwell Method / Masamitsu Honma and Toshio Sofuni
- 8. The In Vitro Micronucleus Assay / Marilyn J. Aardema and Micheline Kirsch-Volders
- 9. ICH Guidances of Genotoxicity and Carcinogenicity: Scientific Background and Regulatory Practice / Lutz Muller, Peter Kasper and Leonard Schechtman
- 10. New OECD Genetic Toxicology Guidelines and Interpretation of Results / Michael C. Cimino
- 11. Dose-Response Relationships in Chemical Carcinogenesis and Cancer Risk Assessment / Werner K. Lutz
- 12. Molecular Epidemiology and Biomarkers / Jia-Sheng Wang, Jonathan M. Links and John D. Groopman
- 13. Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens / Anna M. Fan and Robert A. Howd
- 14. Risk Assessment of Genotoxic Carcinogens / Lauren Zeise
- 15. Biologically Based Cancer Risk Assessment Models / Suresh H. Moolgavkar.
- 1 Human Cancer Genetics / Jason W. Barlow and David Malkin
- 2. Genetic Toxicity Tests for Predicting Carcinogenicity / Errol Zeiger
- 3. Genotoxic and Nongenotoxic Mechanisms of Carcinogenesis / Wai Nang Choy
- 4. Structure-Activity Relationship (SAR) and Its Role in Cancer Risk Assessment / David Y. Lai and Yin-tak Woo
- 5. Regulatory Genetic Toxicology Tests / Wai Nang Choy
- 6. Complementary Genetic Toxicology Assays / B. Bhaskar Gollapudi
- 7. The Mouse Lymphoma Assay (MLA) Using the Microwell Method / Masamitsu Honma and Toshio Sofuni
- 8. The In Vitro Micronucleus Assay / Marilyn J. Aardema and Micheline Kirsch-Volders
- 9. ICH Guidances of Genotoxicity and Carcinogenicity: Scientific Background and Regulatory Practice / Lutz Muller, Peter Kasper and Leonard Schechtman
- 10. New OECD Genetic Toxicology Guidelines and Interpretation of Results / Michael C. Cimino
- 11 Dose-Response Relationships in Chemical Carcinogenesis and Cancer Risk Assessment / Werner K. Lutz
- 12. Molecular Epidemiology and Biomarkers / Jia-Sheng Wang, Jonathan M. Links and John D. Groopman
- 13. Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens / Anna M. Fan and Robert A. Howd
- 14. Risk Assessment of Genotoxic Carcinogens / Lauren Zeise
- 15. Biologically Based Cancer Risk Assessment Models / Suresh H. Moolgavkar.