The kinetochore : from molecular discoveries to cancer therapy /
Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "Th...
| Other Authors: | , |
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| Format: | Book |
| Language: | English |
| Published: |
New York, NY :
Springer,
c2009
New York, NY : ©2009 |
| Subjects: |
| Summary: | Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs |
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| Physical Description: | 1 online resource (xiii, 509 p., [6] p. of plates) : ill. (some col.) 1 online resource (xiii, 509 pages, 6 unnumbered pages of plates) : illustrations (some color) |
| Bibliography: | Includes bibliographical references and index |
| ISBN: | 0387690735 038769076X (electronic bk.) 038769076X 1281953954 6611953957 (electronic bk.) 6611953957 9780387690735 9780387690766 (electronic bk.) 9780387690766 9781281953957 9786611953959 (electronic bk.) 9786611953959 |